2002 Clinical Trial : Thunder God Vine in Refractory RA

2002 Clinical Trial : Thunder God Vine in Refractory RA
September 21, 2017 Nathalie

Refractory RA patients

This small study examines the safety and efficacy of Thunder God Vine TEA medicinal extract in the treatment of patients with refractory RA (Rheumatoid Arthritis).

In a word, refractory RA means that for these people conventional therapy had failed.

Rheumatoid Arthritis = RA

Here is the link to the full study which is available from the Wiley Online Library website (publisher).
Benefit of an Extract of Tripterygium Wilfordii Hook F in Patients With Rheumatoid Arthritis: A Double-Blind, Placebo-Controlled Study

The duration of the study was of 20 weeks (5 months). The clinical trial included 35 patients with active refractory Rheumatoid Arthritis. Patients were required to have failed an adequate treatment with at least 1, but no more than 4 DMARDs.

3 Groups: Placebo / Low dose extract / High dose extract

  • The first group took a placebo,
  • The second group took 180 mg/day of Thunder God Vine TEA medicinal extract,
  • The third group took 360 mg/day of Thunder God Vine TEA medicinal extract.

Here I quote

“The ethanol/ethyl acetate extract of TWHF shows therapeutic benefit in patients with treatment-refractory RA. At therapeutic dosages, the TWHF extract was well tolerated by most patients in this study.”

Other interesting facts

Patients stopped their treatments 4 weeks before entering the trial. Some patients took anti inflammatory drugs such as Prednisone not over 7.5 mg per day and/or NSAIDs. They were required to take the same stable dosage throughout the trial.

The most common side effect was diarrhea. It caused 1 patient in the high-dose group to withdraw from the trial. The trial is on a very small number of persons, but the results are nonetheless highly significant.

TEA medicinal extract ?

The Thuner God Vine TEA medicinal extract goes for Texas Ethanol/Ethyl Acetate extract. The TEA was an extract developed in Texas. It is closely related to its Chinese counterpart, the CEA extract. You can read more about it on this page: The different types of Thunder God Vine extracts.

Here I quote the conclusion of the study

” In conclusion, the ethanol/ethyl acetate extract of TWHF, at a dosage of 360 mg/day, appears to be safe in RA patients. The symptoms and signs of inflammation and the physical functioning of most of the patients in the trial improved.”


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