mTGV vs Acitretin in Moderate to Severe Psoriasis Vulgaris (2015)
To illustrate the efficacy of medicinal Thunder God Vine in Psoriasis, this study is quite interesting, as it features the improvement of Psoriasis over a very short period of time.
mTGV = medicinal Thunder God Vine = Tripterygium wilfordii Hook F = TwHF = Lei Gong Teng
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Quoting the introduction of the study
“Extracts of the Chinese herb Tripterygium wilfordii Hook F (TwHF) (mTGV), also known as “Lei Gong Teng,” are used as one of the most common systemic treatments for inflammatory and immune disorders including psoriasis, rheumatoid arthritis (RA), Crohn’s disease, nephritis, and systemic lupus erythematosus.”
Summary of the study
The study included 115 patients with moderate to severe Psoriasis Vulgaris (affecting at least 10% of the body surface).
The goal was to compare the efficacy and safety of mTGV to that of Acitretin over a period of 8 weeks.
- 58 patients took mTGV. The dosage is of 1 to 1,5 mg/kg/day. Patients took 60mg / day (in 3 times after meals). This is the equivalent of the lower dosage basis for a 60kg patient.
- 57 patients took Acitretin at the dose of 30mg/day. Usually, the maintenance dose is of 25 to 50 mg orally once a day.
Conclusion of the study
“There was no significant difference in treatment efficacy between the TwHF (mTGV) and Acitretin groups within 8 weeks, but there were fewer treatment-related adverse events in the TwHF (mTGV) group.”